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Open flap debridement of peri-implantitis with or without adjunctive systemic antibiotics: a randomized clinical trial.
Malmö University.
Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL).ORCID-id: 0000-0002-3620-5978
Halland's hospital.
Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL).ORCID-id: 0000-0003-0992-2362
2017 (engelsk)Inngår i: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 44, nr 12, 1285-1293 s.Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

AIMS: To investigate clinical, radiographic and microbiological outcome over 12 months following open flap debridement of peri-implantitis with or without antibiotics.

MATERIALS AND METHODS: Peri-implantitis was surgically treated with or without Zithromax(®) in 19 control and 20 test individuals. Probing pocket depth (PPD), gingival inflammation (BOP), intra-oral radiographs and microbial samples were studied. Per protocol, and intent to treat analyzes were performed.

RESULTS: The mean difference (reduction) in PPD values between baseline and month 12 in the test and control groups were: 1.7 mm (SD ± 1.1, 95% CI: 1.1, 2.3, p < 0.001), and 1.6 mm (SD ± 1.5, 95% CI: 0.8, 2,4, p < 0.001), respectively. Data analysis failed to show study group differences for BOP, PPD, radiographic bone level, and microbial load. Succesful treatment (per protocol: PPD≤ 5 mm, no BOP, no suppuration and no bone loss ≥ 0.5 mm) at 12 months in test and control groups were 7/15 (46.7%), and 4/16 (25.0%). Bacterial load reduction was similar in study groups with a temporary reduction following treatment.

CONCLUSIONS: Surgical treatment of peri-implantitis with adjunctive systemic azithromycin did not provide one-year clinical benefits in comparison to those only receiving open flap debridement. This article is protected by copyright. All rights reserved.

sted, utgiver, år, opplag, sider
2017. Vol. 44, nr 12, 1285-1293 s.
Emneord [en]
Antibiotics, microbiota, peri-implantitis, surgical treatment
HSV kategori
Identifikatorer
URN: urn:nbn:se:hkr:diva-17142DOI: 10.1111/jcpe.12805ISI: 000417120000011PubMedID: 28836279OAI: oai:DiVA.org:hkr-17142DiVA: diva2:1137079
Tilgjengelig fra: 2017-08-30 Laget: 2017-08-30 Sist oppdatert: 2018-01-09bibliografisk kontrollert

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