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Effectiveness of enamel matrix derivative on the clinical and microbiological outcomes following surgical regenerative treatment of peri-implantitis: a randomized controlled trial
Umeå university.
Uppsala university.
Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Oral hälsa och folkhälsovetenskap. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL).ORCID-id: 0000-0003-0992-2362
Örebro university.
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2016 (Engelska)Ingår i: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 43, nr 10, s. 863-873Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVE: This randomized clinical trial aimed at comparing radiological, clinical and microbial effects of surgical treatment of peri-implantitis alone or in combination with enamel matrix derivative (EMD).

METHODS: Twenty-six subjects were treated with open flap debridement and decontamination of the implant surfaces with gauze and saline preceding adjunctive EMD or no EMD. Bone level (BL) change was primary outcome and secondary outcomes were changes in pocket depth (PD), plaque, pus, bleeding and the microbiota of the peri-implant biofilm analyzed by the Human Oral Microbe Identification Microarray over a time period of 12 months.

RESULTS: In multivariate modelling, increased marginal BL at implant site was significantly associated with EMD, the number of osseous walls in the peri-implant bone defect and a Gram+/aerobic microbial flora, whereas reduced BL was associated with a Gram-/anaerobic microbial flora and presence of bleeding and pus, with a cross-validated predictive capacity (Q(2) ) of 36.4%. Similar, but statistically non-significant, trends were seen for BL, PD, plaque, pus and bleeding in univariate analysis.

CONCLUSION: Adjunctive EMD to surgical treatment of peri-implantitis was associated with prevalence of Gram+/aerobic bacteria during the follow-up period and increased marginal BL 12 months after treatment.

Ort, förlag, år, upplaga, sidor
2016. Vol. 43, nr 10, s. 863-873
Nyckelord [en]
EMD treatment, bone level, microbiota, peri-implantitis
Nationell ämneskategori
Odontologi
Identifikatorer
URN: urn:nbn:se:hkr:diva-15964DOI: 10.1111/jcpe.12583ISI: 000388357000008PubMedID: 27418458OAI: oai:DiVA.org:hkr-15964DiVA, id: diva2:968141
Tillgänglig från: 2016-09-12 Skapad: 2016-09-12 Senast uppdaterad: 2017-11-21Bibliografiskt granskad

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Renvert, Stefan

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Avdelningen för Oral hälsa och folkhälsovetenskapForskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL)
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