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Low expression of SHP-2 is associated with less favourable outcome of prostate cancer
Lund University.ORCID-id: 0000-0003-4190-5431
Lund University.
Lund University.
Skåne University Hospital, Malmö.
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2013 (Engelska)Ingår i: Tumor Biology, ISSN 1010-4283, E-ISSN 1423-0380, Vol. 34, nr 2, s. 637-642Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Src homology 2 domain-containing tyrosine phosphatase-2 (SHP-2) is an important regulator of cell signaling because of its ability to dephosphorylate receptors of growth factors as well as the cytokines and tyrosine-phosphorylated proteins associated with these receptors. In the current study, we used four different prostate cancer cell lines: PC3, DU145, LNCaP and LNCaP-IL6+. Tumor specimens from 122 patients with prostate cancer were analyzed using a tissue microarray. Our data demonstrate that all four prostate cancer cell lines express the SHP-2 protein. Additionally, low staining intensity and SHP-2 expression in the cytoplasm of cancer cells in prostate tumor specimens was inversely correlated with prostate volume (p = 0.041 and p = 0.042, respectively) whereas nuclear staining was positively correlated with extracapsular extension (p = 0.039). In our post-prostatectomy specimens, we found that patients with low SHP-2 expression had less favorable outcomes with respect to biochemical recurrence and clinical progression (p = 0.005 and p = 0.018, respectively). The loss of cytoplasmic SHP-2 expression is associated with increased growth and prostatic cancer progression.

Ort, förlag, år, upplaga, sidor
2013. Vol. 34, nr 2, s. 637-642
Nationell ämneskategori
Cell- och molekylärbiologi
Identifikatorer
URN: urn:nbn:se:hkr:diva-14765DOI: 10.1007/s13277-012-0590-1ISI: 000316364500004PubMedID: 23192641OAI: oai:DiVA.org:hkr-14765DiVA, id: diva2:856535
Tillgänglig från: 2015-09-24 Skapad: 2015-09-24 Senast uppdaterad: 2018-01-11Bibliografiskt granskad

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Tassidis, Helena

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