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Relation of gelsolin amyloidosis and periodontal health
Finland.
Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Hälsovetenskap III. Högskolan Kristianstad, Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet.ORCID-id: 0000-0002-3620-5978
Finland.
Finland.
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2015 (Engelska)Ingår i: Clinical Oral Investigations, ISSN 1432-6981, E-ISSN 1436-3771, Vol. 19, nr 2, s. 229-235Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVE: Hereditary gelsolin amyloidosis (AGel amyloidosis) is a rare, dominantly inherited systemic disease with worldwide distribution, caused by a gelsolin gene mutation. We studied the periodontal conditions and microbiological plaque composition of AGel amyloidosis patients.

MATERIAL AND METHODS: A voluntary study group of 36 AGel amyloidosis patients (mean age 61) filled in a questionnaire. A thorough periodontal examination included periodontal pocket depth and attachment level measurements, registrations of visible plaque, bleeding on probing and panoramic radiographs. The presence of oral Candida was studied by fungal culture method. Bacterial samples from deepened pockets (≥4 mm) were analyzed with checkerboard DNA-DNA hybridization method.

RESULTS: VPI (15.3 %) and BOP (11.2 %) of the patients were modest reflecting relatively adequate oral self-care. Still 89 % of the patients had at least one PPD of ≥4 mm; 78.5 % of the PPDs ≥6 mm were found in molars. Patients had lost one third of the molars due to periodontitis and/or tooth decay. Half of the patients (53 %) were Candida carriers. Bacterial analysis of subgingival plaque samples revealed bacterial species common to chronic periodontitis.

CONCLUSION: AGel amyloidosis may increase the risk for periodontitis even when the oral self-care is adequate. Molar teeth appear to be mostly affected, leading to tooth loss.

CLINICAL RELEVANCE: AGel amyloidosis as a systemic disease is related with a vast variety of symptoms with variable severity. Even though a causal relationship of the systemic disease and periodontitis has not yet been proven, increased risk for periodontal problems should be considered when examining AGel amyloidosis patients.

Ort, förlag, år, upplaga, sidor
2015. Vol. 19, nr 2, s. 229-235
Nyckelord [en]
Hereditary amyloidosis, Gelsolin, Periodontitis, Oral microbiota
Nationell ämneskategori
Odontologi
Identifikatorer
URN: urn:nbn:se:hkr:diva-13056DOI: 10.1007/s00784-014-1254-xPubMedID: 24852333OAI: oai:DiVA.org:hkr-13056DiVA, id: diva2:753181
Tillgänglig från: 2014-10-07 Skapad: 2014-10-07 Senast uppdaterad: 2017-12-05Bibliografiskt granskad

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Persson, G. Rutger

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