hkr.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study
Division of ENT Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet.
Department of Biological Sciences, National University of Singapore.
Högskolan Kristianstad, Sektionen för lärande och miljö, Avdelningen för Naturvetenskap. Högskolan Kristianstad, Forskningsmiljön Biomedicin.ORCID-id: 0000-0002-9355-3901
Department of Otolaryngology, National University of Singapore.
Visa övriga samt affilieringar
2012 (Engelska)Ingår i: BMC Medical Genetics, ISSN 1471-2350, E-ISSN 1471-2350, Vol. 13, nr 1, s. 66-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND:The Toll-like receptor proteins are important in host defense and initiation of the innate and adaptive immune responses. A number of studies have identified associations between genetic variation in the Toll-like receptor genes and allergic disorders such as asthma and allergic rhinitis. The present study aim to search for genetic variation associated with allergic rhinitis in the Toll-like receptor genes.

METHODS:A first association analysis genotyped 73 SNPs in 182 cases and 378 controls from a Swedish population. Based on these results an additional 24 SNPs were analyzed in one Swedish population with 352 cases and 709 controls and one Chinese population with 948 cases and 580 controls.

RESULTS:The first association analysis identified 4 allergic rhinitis-associated SNPs in the TLR7-TLR8 gene region. Subsequent analysis of 24 SNPs from this region identified 7 and 5 significant SNPs from the Swedish and Chinese populations, respectively. The corresponding riskassociated haplotypes are significant after Bonferroni correction and are the most common haplotypes in both populations. The associations are primarily detected in females in the Swedish population, whereas it is seen in males in the Chinese population. Further independent support for the involvement of this region in allergic rhinitis was obtained from quantitative skin prick test data generated in both populations.

CONCLUSIONS:Haplotypes in the TLR7-TLR8 gene region were associated with allergic rhinitis in one Swedish and one Chinese population. Since this region has earlier been associated with asthma and allergic rhinitis in a Danish linkage study this speaks strongly in favour of this region being truly involved in the development of this disease.

Ort, förlag, år, upplaga, sidor
2012. Vol. 13, nr 1, s. 66-
Nyckelord [en]
Allergic rhinitis, Toll-like receptor, Polymorphism, Genetics, Haplotype, Case–control
Nationell ämneskategori
Medicinsk genetik
Identifikatorer
URN: urn:nbn:se:hkr:diva-9618DOI: 10.1186/1471-2350-13-66ISI: 000309423900001OAI: oai:DiVA.org:hkr-9618DiVA, id: diva2:546287
Tillgänglig från: 2012-08-23 Skapad: 2012-08-23 Senast uppdaterad: 2018-01-12Bibliografiskt granskad

Open Access i DiVA

fulltext(305 kB)494 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 305 kBChecksumma SHA-512
0ae71f4969b55e1d32e67bc4932e1cd5edfe015c8a9a40ca60629f58f566183e3851ebf5543e1de5abdf39a57aa758cc897d29ac1c4cab6718e5f0537c895124
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltext

Personposter BETA

Halldén, ChristerSäll, Torbjorn

Sök vidare i DiVA

Av författaren/redaktören
Halldén, ChristerSäll, Torbjorn
Av organisationen
Avdelningen för NaturvetenskapForskningsmiljön Biomedicin
I samma tidskrift
BMC Medical Genetics
Medicinsk genetik

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 494 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 200 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf