Uncertainty is a well-known phenomenon that is recurring in biographies, imaginative literature and science, but is less studied in nursing science. The aim of this participatory action research project was to, in collaboration with nursing students; explore nursing activities for relieving patients’ uncertainty. A qualitative approach was chosen with focus groups and the text was content analyzed. The students studied their third semester on a nursing program. The findings showed two different kinds of uncertainty, existential uncertainty and care evoked uncertainty. Relieving uncertainty showed to be a process in three steps. The first step is to reach deeper understanding of what uncertainty is and how it affects patients. The second step is to develop sensibility for how to discover uncertainty and the third step is to use uncertainty relieving strategies. To do this requires courage and a wish to share power with the patient. The strategies for relieving existential and care evoked uncertainty differed.