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Dual effect of amino modified polystyrene nanoparticles on amyloid β protein fibrillation
Irland.ORCID-id: 0000-0002-3200-9945
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2010 (Engelska)Ingår i: ACS Chemical Neuroscience, ISSN 1948-7193, E-ISSN 1948-7193, Vol. 1, nr 4, s. 279-87Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The fibrillation kinetics of the amyloid β peptide is analyzed in presence of cationic polystyrene nanoparticles of different size. The results highlight the importance of the ratio between the peptide and particle concentration. Depending on the specific ratio, the kinetic effects vary from acceleration of the fibrillation process by reducing the lag phase at low particle surface area in solution to inhibition of the fibrillation process at high particle surface area. The kinetic behavior can be explained if we assume a balance between two different pathways: first fibrillation of free monomer in solution and second nucleation and fibrillation promoted at the particle surface. The overall rate of fibrillation will depend on the interplay between these two pathways, and the predominance of one mechanism over the other will be determined by the relative equilibrium and rate constants.

Ort, förlag, år, upplaga, sidor
2010. Vol. 1, nr 4, s. 279-87
Nyckelord [en]
Amyloid, aggregation kinetics, nanoparticles
Nationell ämneskategori
Fysikalisk kemi
Identifikatorer
URN: urn:nbn:se:hkr:diva-18585DOI: 10.1021/cn900027uPubMedID: 22778827OAI: oai:DiVA.org:hkr-18585DiVA, id: diva2:1241316
Tillgänglig från: 2018-08-23 Skapad: 2018-08-23 Senast uppdaterad: 2018-08-29Bibliografiskt granskad

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Cabaleiro-Lago, Celia
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ACS Chemical Neuroscience
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