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Measuring the impact of drug-induced dyskinesias in Parkinson’s disease: the PDYS-26 revisited
Högskolan Kristianstad, Fakulteten för hälsovetenskap, Forskningsmiljön PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education. Högskolan Kristianstad, Forskningsplattformen för Hälsa i samverkan. Högskolan Kristianstad, Fakulteten för hälsovetenskap, Avdelningen för sjuksköterskeutbildningarna och integrerad hälsovetenskap.ORCID-id: 0000-0003-2174-372X
Högskolan Kristianstad, Fakulteten för hälsovetenskap, Forskningsmiljön PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education. Högskolan Kristianstad, Forskningsplattformen för Hälsa i samverkan. Högskolan Kristianstad, Fakulteten för hälsovetenskap, Avdelningen för sjuksköterskeutbildningarna och integrerad hälsovetenskap.ORCID-id: 0000-0003-4820-6203
Umeå University.
England.
Visa övriga samt affilieringar
2018 (Engelska)Ingår i: International Conference on Probabilistic Models for Measurement, 2018Konferensbidrag, Muntlig presentation med publicerat abstract (Övrigt vetenskapligt)
Abstract [en]

BACKGROUND: Drug-induced dyskinesias (DID) are a common long-term complication of dopaminergic drug therapy for Parkinson’s disease (PD). The 26-item PD dyskinesia scale (PDYS-26) is a patient-reported rating scale intended to quantify the everyday impact of DID. However, its measurement properties have not been scrutinized since its development some 10 years ago.

AIM: To examine the measurement properties of the PDYS-26 using Rasch Measurement Theory (RMT).

DESIGN: The PDYS-26 was administered to people with PD and varying degrees of DID recruited from six Swedish (n=172) and three British (n=150) outpatient movement disorder clinics. RMT analyses were conducted using the RUMM2030 software.

RESULTS: RMT model fit was generally good with only three items exhibiting relatively minor misfit. Response categories worked as intended and targeting was acceptable and reliability was 0.96. There was no differential item functioning (DIF) by age, PD duration or time, but three items exhibited DIF by country and one by sex, neither of which appear to notably bias person measurement. Item hierarchy review suggested a variable of dubious clinical/theoretical coherence. Therefore, a recently proposed three-dimensional reduced (21-item) PDYS version was explored. Results were similar to those from the original scale but with improved conceptual coherence, albeit with close to a 2- to 3-fold decrease in measurement precision. 

SUMMARY AND IMPLICATIONS: The PDYS-26 appears useful for measuring the impact of DID, and yields sufficiently invariant measurement across core patient subgroups. Scale reconceptualization improves the meaning of scores, but at the cost of measurement uncertainty.

Ort, förlag, år, upplaga, sidor
2018.
Serie
International Conference on Probabilistic Models for Measurement
Nationell ämneskategori
Hälsovetenskaper Neurologi
Identifikatorer
URN: urn:nbn:se:hkr:diva-18466OAI: oai:DiVA.org:hkr-18466DiVA, id: diva2:1237952
Konferens
The 7th International Conference on Probabilistic Models for Measurement. Perth, WA, Australia, 2018
Tillgänglig från: 2018-08-10 Skapad: 2018-08-10 Senast uppdaterad: 2018-08-15Bibliografiskt granskad

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Av författaren/redaktören
Hagell, PeterWestergren, Albert
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Forskningsmiljön PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and EducationForskningsplattformen för Hälsa i samverkanAvdelningen för sjuksköterskeutbildningarna och integrerad hälsovetenskap
HälsovetenskaperNeurologi

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