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Determination of thirteen antibiotics in drug products: a new LC-MS/MS tool for screening drug product quality
Faculty of Health and Medical Sciences, University of Copenhagen.
Faculty of Health and Medical Sciences, University of Copenhagen.
Högskolan Kristianstad, Plattformen för molekylär analys. Högskolan Kristianstad, Fakulteten för naturvetenskap, Avdelningen för miljö- och biovetenskap. Högskolan Kristianstad, Fakulteten för naturvetenskap, Forskningsmiljön MoLab. Faculty of Health and Medical Sciences, University of Copenhagen.ORCID-id: 0000-0003-2283-2927
Faculty of Health and Medical Sciences, University of Copenhagen.
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2014 (engelsk)Inngår i: Analytical Methods, ISSN 1759-9660, E-ISSN 1759-9679, Vol. 6, s. 5847-5855Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Poor quality antibiotic medicines in circulation in Sub-Saharan Africa continue to be a burden. Pharmaceutical trade in substandard and counterfeit medicines is on the rise. The chemical quality of antibiotics dispensed in health facilities and recognised drug outlets in Ghana, when compromised, could be a major drawback to efforts made in fighting antibiotic resistance globally. To improve on antibiotic drug quality monitoring, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodology, which is capable of quantifying thirteen antibiotics in drug products, was developed and validated in present work. The methodology was applied to various drug products including tablets, capsules, suspensions, syrups, intravenous and injection solutions as well as ear and eye droplets used as essential medicines in a Sub-Saharan country, Ghana.

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2014. Vol. 6, s. 5847-5855
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URN: urn:nbn:se:hkr:diva-14451DOI: 10.1039/C4AY00748DOAI: oai:DiVA.org:hkr-14451DiVA, id: diva2:846185
Tilgjengelig fra: 2015-08-14 Laget: 2015-08-13 Sist oppdatert: 2019-07-03bibliografisk kontrollert

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