Based on previous research readiness for strategic change has found to impact employee commitment and flexibility positively, by increasing the willingness to embrace and adapt changes faster. However, the relationship has mainly been investigated within the health care industry or from a national perspective, but lacks empirical research taking organizational culture into account. This study aims to investigate the relationship between readiness for strategic change, employee commitment and flexibility, with organizational culture as a moderating factor. The survey was conducted at an organization belonging to a multinational company including participants in four different countries. The results only showed partial support for the investigated relationship, and significant differentials between areas was also found to be present. A main finding was the major impact by organizational culture for employee commitment and flexibility at the presence of strategic changes.