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Periodontitis: a future risk of acute coronary syndrome?: A follow-up study over 3 years
Högskolan Kristianstad, Sektionen för hälsa och samhälle. (Oral hälsa)ORCID-id: 0000-0003-0992-2362
Högskolan Kristianstad, Sektionen för hälsa och samhälle.
Department of Medicine, Kristianstad Central Hospital.
Department of Periodontology, University of Bern.ORCID-id: 0000-0002-3620-5978
2010 (engelsk)Inngår i: Journal of Periodontology, ISSN 0022-3492, E-ISSN 1943-3670, Vol. 81, nr 7, s. 992-1000Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Periodontitis has been associated with cardiovascular disease. We assess if the recurrence of acute coronary syndrome (ACS) could be predicted by preceding medical and periodontal conditions. Methods: A total of 165 consecutive subjects with ACS and 159 medically healthy, matched control subjects were examined and followed for 3 years. Periodontitis was defined by alveolar bone loss. Subgingival microbial samples were studied by the checkerboard DNA-DNA hybridization method. Results: The recurrence of ACS was found in 66 of 165 (40.0%) subjects, and a first ACS event was found in seven of 159 (4.4%) subjects among baseline control subjects. Subjects who later had a second ACS event were older (P<0.001). Significantly higher serum levels of high-density lipoprotein (P <0.05), creatinine (P <0.01), and white blood cell (WBC) counts (P <0.001) were found in subjects with future ACS. Periodontitis was associated with a first event of ACS (crude odds ratio [OR]: 10.3:1; 95% confidence interval [CI]: 6.1 to 17.4; P <0.001) and the recurrence of ACS (crude OR: 3.6:1; 95% CI: 2.0 to 6.6; P <0.001). General linear modeling multivariate analysis, controlling for age and the prediction of a future ACS event, identified that WBC counts (F = 20.6; P <0.001), periodontitis (F = 17.6; P <0.001), and serum creatinine counts (F = 4.5; P<0.05) were explanatory of a future ACS event. Conclusions: The results of this study indicate that recurrent ACS events are predicted by serum WBC counts, serum creatinine levels, and a diagnosis of periodontitis. Significantly higher counts of putative pathogens are found in subjects with ACS, but these counts do not predict future ACS events.

sted, utgiver, år, opplag, sider
2010. Vol. 81, nr 7, s. 992-1000
Emneord [en]
Inflammation, myocardial infarction, periodontitis, recurrence, serum inflammatory markers, dna-dna hybridization, cardiovascular-disease risk, acute myocardial-infarction, heart-disease, systemic inflammation, endothelial dysfunction, european-society, atherosclerosis, therapy
HSV kategori
Identifikatorer
URN: urn:nbn:se:hkr:diva-7533DOI: 10.1902/jop.2010.090105ISI: 000283021400006PubMedID: 20350154OAI: oai:DiVA.org:hkr-7533DiVA, id: diva2:380375
Tilgjengelig fra: 2010-12-21 Laget: 2010-12-20 Sist oppdatert: 2017-12-11bibliografisk kontrollert

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