Mulitresistent staphylococcus aureus (MRSA) is a bacteria that is resistent against penicillin, this makes it difficulte to treat. MRSA causes woundinfections and other seriouse conditions. If MRSA establishes in an hospital environment it often spreads fast. Common ways of spreading MRSA is through direct or indirect contact. The nurse should work according to guidelines, apply hygienic routines and prevent the spread of infections. Aim: The aim of the literaturestudie was to illustrate factors that affects nurses care of patients carrying MRSA. Method: A literature study was carried out. Results: the study found four categories: knowledge, attitudes, guidelines and risk. They showed that nurses had to little knowledge about MRSA and the preventive routines that ought to be followed. If the nurse had knowledge she also had a positive attitude and was able to give same care to the patient carrying MRSA as to the ones that not carrying it. Conclusion: Knowledge, attitudes and guidelines about MRSA needs to be improved. This gives a better care of MRSA infected patients and decreases the infections risks for both medical personel and patients.