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Karlgren-Andersson, Pernilla
Publications (2 of 2) Show all publications
Widén, C., Erovic Ademovski, S., Karlgren-Andersson, P., Sättlin, S. & Wallin Bengtsson, V. (2017). Hälsoklinik på Tandhygienistprogrammet. Högskolepedagogisk debatt (2), 29-34
Open this publication in new window or tab >>Hälsoklinik på Tandhygienistprogrammet
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2017 (Swedish)In: Högskolepedagogisk debatt, ISSN 2000-9216, no 2, p. 29-34Article in journal (Other (popular science, discussion, etc.)) Published
Place, publisher, year, edition, pages
Kristianstad: Kristianstad University Press, 2017
National Category
Pedagogy
Identifiers
urn:nbn:se:hkr:diva-17708 (URN)
Available from: 2017-12-18 Created: 2017-12-18 Last updated: 2017-12-18Bibliographically approved
Widén, C., Coleman, M., Critén, S., Karlgren-Andersson, P., Renvert, S. & Persson, G. R. (2015). Consumption of bilberries controls gingival inflammation. International Journal of Molecular Sciences, 16(5), 10665-73
Open this publication in new window or tab >>Consumption of bilberries controls gingival inflammation
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2015 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 16, no 5, p. 10665-73Article in journal (Refereed) Published
Abstract [en]

Bioactive molecules in berries may be helpful in reducing the risk of oral diseases. The aim of this study was to determine the effect of bilberry consumption on the outcome of a routine dental clinical parameter of inflammation, bleeding on probing (BOP), as well as the impact on selected biomarkers of inflammation, such as cytokines, in gingival crevicular fluid (GCF) in individuals with gingivitis. Study individuals who did not receive standard of care treatment were allocated to either a placebo group or to groups that consumed either 250 or 500 g bilberries daily over seven days. The placebo group consumed an inactive product (starch). A study group, receiving standard of care (debridement only) was also included to provide a reference to standard of care treatment outcome. Cytokine levels were assayed using the Luminex MagPix system. The mean reduction in BOP before and after consumption of test product over 1 week was 41% and 59% in the groups that consumed either 250 or 500 g of bilberries/day respectively, and was 31% in the placebo group, and 58% in the standard of care reference group. The analysis only showed a significant reduction in cytokine levels in the group that consumed 500 g of bilberries/day. A statistically significant reduction was observed for IL-1b (p = 0.025), IL-6 (p = 0.012) and VEGF (p = 0.017) in GCF samples in the group that consumed 500 g of bilberries daily. It appears that berry intake has an ameliorating effect on some markers of gingival inflammation reducing gingivitis to a similar extent compared to standard of care.

Keywords
bleeding, clinical study, cytokines, gingival crevicular fluid, human
National Category
Dentistry
Identifiers
urn:nbn:se:hkr:diva-13928 (URN)10.3390/ijms160510665 (DOI)000356241400092 ()25970751 (PubMedID)
Funder
Knut and Alice Wallenberg Foundation
Available from: 2015-05-25 Created: 2015-05-22 Last updated: 2017-12-04Bibliographically approved
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